Blar i forfatter "Laurvik, Helene"

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    • A combined histo-score based on tumor differentiation and lymphocytic infiltrate is a robust prognostic marker for mobile tongue cancer 

      Bjerkli, Inger-Heidi; Hadler-Olsen, Elin Synnøve; Nginamau, Elisabeth Sivy; Laurvik, Helene; Søland, Tine Merete; Costea, Daniela Elena; Uhlin-Hansen, Lars; Steigen, Sonja Eriksson (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-30)
      We wanted to evaluate the prognostic value of common histopathological variables in a large cohort of patients with cancer in the mobile tongue as such information can be important for treatment stratification of the individual patient, especially for patients with low-stage disease. In addition, we wanted to investigate whether an alternative scoring model with fewer options would compromise the ...

    • Grading of oral squamous cell carcinomas – Intra and interrater agreeability: Simpler is better? 

      Steigen, Sonja E; Søland, Tine Merete; Nginamau, Elisabeth Sivy; Laurvik, Helene; Costea, Daniela-Elena; Johannessen, Anne Christine; Jebsen, Peter Wilhelm; Bjerkli, Inger-Heidi; Uhlin-Hansen, Lars; Hadler-Olsen, Elin Synnøve (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-03)
      <i>Background</i> - Numerous studies have been presented on histological grading of oral squamous cell carcinomas (OSCC) for predicting survival, but uncertainty of their usefulness rises due to discordances of results. A scoring system should be robust and well validated, and intra‐ and interrater agreement can be used as a tool to visualize the strength of reproducibility.<p><p> <i>Methods</i> ...

    • High-risk human papilloma virus was not detected in a Norwegian cohort of oral squamous cell carcinoma of the mobile tongue 

      Søland, Tine Merete; Bjerkli, Inger-Heidi; Georgsen, Jeanette B; Schreurs, Olaf Joseph Franciscus; Jebsen, Peter Wilhelm; Laurvik, Helene; Sapkota, Dipak (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-03)
      <p><i>Objectives - </i>The presence of and the causative role of high‐risk human papilloma virus (HPV) is a subject of controversy in oral squamous cell carcinoma (OSCC). The disagreement can be related to the misclassification of OSCC as oropharyngeal squamous cell carcinoma and/or lack of standard detection methods. This study aimed to examine the presence of transcriptionally active high‐risk HPV ...

    • Tumor budding score predicts lymph node status in oral tongue squamous cell carcinoma and should be included in the pathology report 

      Bjerkli, Inger-Heidi; Laurvik, Helene; Nginamau, Elisabeth Sivy; Søland, Tine Merete; Costea, Daniela Elena; Hov, Håkon; Uhlin-Hansen, Lars; Hadler-Olsen, Elin Synnøve; Steigen, Sonja Eriksson (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-25)
      <i>Background</i> - The majority of oral cavity cancers arise in the oral tongue. The aim of this study was to evaluate the prognostic value of tumor budding in oral tongue squamous cell carcinoma, both as a separate variable and in combination with depth of invasion. We also assessed the prognostic impact of the 8th edition of the American Joint Committee on Cancer’s TNM classification (TNM8), where ...